CRC 235 Emergence of Life

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Dass A.V., S. Wunnava, J. Langlais, B. von der Esch, M. Krusche, L. Ufer, et al. (2022) "RNA polymerisation without catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces." ChemRxiv. doi: 10.26434/chemrxiv-2022-zwh2t-v2


Doppleb, O. , R.J. Schwarz, M. Landa, C. Richert (2022) "Efficient oligomerization of aromatic amino acids induced by gaps in four-helix bundles of DNA or RNA." Chem. Eur. J. doi: 10.1002/chem.202104104


Gartner, F. M., I. R. Graf, and E. Frey (2022). "The Time Complexity of Self-Assembly." PNAS. doi:10.1073/pnas.2116373119


Göppel , T., J. H. Rosenberger, B. Altaner, and U. Gerland (2022). "Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor." Life. doi: 10.3390/life12040567

nature physics

Ianeselli, A., M. Atienza, P. W. Kudella, U. Gerland, C. B. Mast, and D. Braun (2022). "Water cycles in a Hadean CO2 atmosphere drive the evolution of long DNA." Nat. Phys.  doi:10.1038/s41567-022-01516-z


Jones, T. J., K. V. Cashman, E. J. Liu, A. C. Rust and B. Scheu (2022). "Magma fragmentation: a perspective on emerging topics and future directions." Bulletin of Volcanology 84(5): 45. doi:10.1007/s00445-022-01555-7

physical review letters

Katzmeier, F., B. Altaner, J. List, U. Gerland, and F. C. Simmel (2022). "Emergence of colloidal patterns in AC electrical fields ." Phys. Rev. Lett. doi: 10.1103/PhysRevLett.128.058002


Leveau, G., D. Pfeffer, B. Altaner, E. Kervio, F. Welsch, U. Gerland, and C. Richert (2022). "Enzyme-Free Copying of 12Bases of RNA with Dinucleotides." Angew. Chem. Int. Ed. doi: 10.1002/anie.202203067

rev in min geochem

Scheu, B., and D. B. Dingwell (2022). "Magma Fragmentation." Reviews in Mineralogy and Geochemistry. doi: 10.2138/rmg.2021.87.16


Steffens, L., E. Pettinato, T.M. Steiner, W. Eisenreich and I.A. Berg (2022). "Tracking the reversed oxidative tricarboxylic acid cycle in bacteria ." Bio-protocol. doi: 10.21769/BioProtoc.4364


Sydow C., F. Sauer, A. F. Siegle, and O. Trapp (2022) "Iron-mediated peptide formation in water and liquid sulfur dioxide under early Earth conditions." ChemRxiv. doi: 10.26434/chemrxiv-2022-gr80t




Closs, A., Bechtel, M. and Trapp, O. (2021) "Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System." Angew. Chem. Int. Ed. doi:10.1002/anie.202112563


Colombier, M., J. Vasseur, B.F. Houghton, F. Cáceres, B. Scheu, U. Kueppers, S. Thivet, L. Gurioli, C. Montanaro, A. Soldati, A. Di Muro, D.B. Dingwell (2021) "Degassing and gas percolation in basaltic magmas." Earth and Planetary Science Letters. doi:10.1016/j.epsl.2021.117134


Coskun, Ö.K., Vuillemin, A., Schubotz, F., Klein, F., Sichel, S.E., Eisenreich, W., and Orsi, W.D. (2021) "Quantifying the effects of hydrogen on carbon assimilation in a seafloor microbial community associated with ultramafic rocks." ISME J. doi:10.1038/s41396-021-01066-x

nature communications

Danger, G., V. Vinogradoff, M. Matzka, J-C. Viennet, L. Remusat, S. Bernard, A. Ruf, L. Le Sergeant d’Hendecourt, P. Schmitt-Kopplin (2021). "Exploring the link between molecular cloud ices and chondritic organic matter in laboratory." Nature Communications. doi:10.1038/s41467-021-23895-2


Doppleb, O., Bremer, J., Bechthold, M., Sánchez Rico, C., Göhringer, D., Griesser, H. and Richert, C. (2021) "Determining the Diastereoselectivity of the Formation of Dipeptidonucleotides by NMR Spectroscopy." Chem. Eur. J. doi:10.1002/chem.202101630

2021_von der esch

Esch, B. v. d., L.D.M. Peters, L. Sauerland, C. Ochsenfeld (2021). "Quantitative Comparison of Experimental and Computed IR-Spectra Extracted from Ab Initio Molecular Dynamics." J. Chem. Theory Comput. doi:10.1021/acs.jctc.0c01279


Falgenhauer E., S. von Schönberg, C. Meng, A. Mückl, K. Vogele, Q. Emslander, C. Ludwig, F.C. Simmel (2021). "Evaluation of an E. coli cell extract prepared by lysozyme-assisted sonication via gene expression, phage assembly and proteomics." Chembiochem.
doi: 10.1002/cbic.202100257


Geisberger, T., J. Sobotta, W. Eisenreich, and C. Huber (2021). "Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth - Implications for Early Life on Extraterrestrial Planets? ." Life. doi:10.3390/life11020149


Han, J., Kervio, E., and Richert, C. (2021) "High fidelity enzyme-free primer extension with an ethynylpyridone thymidine analog." Chem. Eur. J. doi:10.1002/chem.202102996


Ianeselli A., D. Tetiker, J. Stein, A. Kühnlein, C. B. Mast, D. Braun, and T.-Y. D. Tang (2021) "Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells." Nat. Chem. doi:10.1038/s41557-021-00830-y


Jash, B., Tremmel, P., Jovanovic, D., and Richert, C. (2021) "Single nucleotide translation without ribosomes." Nat. Chem. doi:10.1038/s41557-021-00749-4


Kriebisch, C.M.E., A. Bergmann, and J. Boekhoven (2021). "Fuel-Driven Dynamic Combinatorial Libraries ." J. Am. Chem. Soc. doi:110.1021/jacs.1c01616


Kudella, P., A.V. Tkachenko, A. Salditt, S. Maslov, and D. Braun (2021). "Structured sequences emerge from random pool when replicated by templated ligation." PNAS. doi:10.1073/pnas.2018830118


Kunze, M., T. Steiner, F. Chen, C. Huber, K. Rydzewski, M. Stämmler, K. Heuner and W. Eisenreich (2021). "Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii." IJMM. doi:10.1016/j.ijmm.2021.151504


Kühnlein, A., S.A. Lanzmich, and D. Braun (2021). "tRNA sequences can assemble into areplicator." eLife. doi:10.7554/eLife.63431


Le Vay, K.K., E.Y. Song, B. Ghosh, D. Tang and H. Mutschler (2021). "Enhanced ribozyme-catalyzed recombination and oligonucleotide assembly in peptide-RNA condensates." Angew. Chem. Int. Ed. doi:10.1002/anie.202109267


Matreux, T., K. LeVay, A. Schmid, P. Aikkila, L. Belohlavek, A. Z. Çalışkanoğlu, E. Salibi,
A. Kühnlein, C. Springsklee, B. Scheu, D. B. Dingwell, D. Braun, H. Mutschler and
C. B. Mast (2021). "Heat flows in rock cracks naturally optimize
salt compositions for ribozymes." Nat. Chem. doi:10.1038/s41557-021-00772-5


Matzka, M., M. Lucio, B. Kanawati, E. Quirico, L. Bonal, S. Loehle, and P. Schmitt-Kopplin (2021). "Thermal History of Asteroid Parent Bodies Is Reflected in Their Metalorganic Chemistry." The Astrophysical Journal Letters. doi:10.3847/2041-8213/ac0727


Mühlbauer, M. E., A. P. Gamiz-Hernandez, and V. R. I. Kaila (2021). "Functional Dynamics of an Ancient Membrane-Bound Hydrogenase." J. Am. Chem. Soc. doi:10.1021/jacs.1c09356

marine geo

Puzenat, V., J. Escartin, J.-E. Martelat, T. Barreyre, S. Le Moine Bauer,  P. Nomikou, N. Gracias, P. Allemand, V. Antoniou, O. Coskun, R. Garcia, P. Grandjean, S.L. Jørgensen, L. Magíf, M. Mandalakis, W. Orsi, P. Polymenakou, A. Schouw, G. Vallicrosa, O. Vlasopoulos (2021). "Shallow-water hydrothermalism at Milos (Greece): Nature, distribution, heat fluxes and impact on ecosystems." Marine Geology. doi:10.1016/j.margeo.2021.106521

physical review x

Rosenberger, J.H., T. Göppel, P.W. Kudella, D. Braun, U. Gerland, and B. Altaner (2021). "Self-assembly of informational polymers by templated ligation ." Physical Review X. doi:10.1103/PhysRevX.11.031055

nature communications

Sauer, F., M. Haas, C. Sydow, A.F. Sigle, C.A. Lauer, and O. Trapp (2021). "From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth." Nature Communications. doi:10.1038/s41467-021-27527-7

chemical science

Schwarz, P., S. Laha, J. Janssen, T. Huss, J. Boekhoven and C. Weber (2021). "Parasitic Behavior in Competing Chemically Fueled Reaction Cycles ." Chemical Science. doi:10.1039/D1SC01106E


Seitz, C., W. Eisenreich, and C. Huber (2021). "The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions—An Initial Step towards Life’s First Breath?." Life. doi:10.3390/life11090980


 Späth, F., C. Donau, A.M. Bergmann, M. Kränzlein, C.V. Synatschke, B. Rieger and J. Boekhoven (2021). "Molecular Design of Chemically Fueled Peptide–Polyelectrolyte Coacervate-Based Assemblies." JACS. doi:10.1021/jacs.1c01148


 Šponer, J.E., J. Šponer, J. Výravský, O. Šedo, Z. Zdráhal, G. Costanzo, E. Di Mauro, S. Wunnava, D. Braun, R. Matyášek, and A. Kovařík (2021). "Non-Enzymatic, Template-Free Polymerization of 3’,5’ Cyclic Guanosine Monophosphate on Mineral Surfaces." ChemSystemsChem. doi:10.1002/syst.202100017


 Steffens, L., E. Pettinato, T.M. Steiner, A. Mall, S. König, W Eisenreich, and I.A. Berg (2021). "High CO2 levels drive the TCA cycle backwards towards autotrophy." Nature doi:10.1038/s41586-021-03456-9


 Stein, J.A.C., A. Ianeselli, and D. Braun (2021). "Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics." Angew. Chem.Int.Ed. doi:10.1002/anie.202101261


 Steiner, T.M., C. Lettl, F. Schindele, W. Goebel, R. Haas, W. Fischer and W. Eisenreich (2021). "Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori." Molecular Microbiology doi:10.1111/mmi.14775


Vogele, K., E. Falgenhauer, S. von Schönberg, F.C. Simmel and T. Pirzer (2021). "Small Antisense DNA-Based Gene Silencing Enables Cell-Free Bacteriophage Manipulation and Genome Replication." ACS Synth. Biol. doi:10.1021/acssynbio.0c00402


Wunnava, S., Dirscherl, C..F., Výravský, J., Kovařík, A., Matyášek, R., Šponer, J., Braun, D. and Šponer, J..E. (2021). "Acid-catalyzed RNA-oligomerization from 3´,5´-cGMP." Chem. Eur. J. doi:10.1002/chem.202103672




Closs, A.C., E. Fuks, M. Bechtel and O. Trapp (2020). "Prebiotically plausible organocatalysts enabling a selective photoredox α‐alkylation of aldehydes on the Early Earth." Chem. Eur. J. doi:10.1002/chem.202001514


Dai, K.,  J. R. Fores, C. Wanzke, B. Winkeljann, A. M. Bergmann, O. Lieleg, and J. Boekhoven (2020). "Regulating chemically fueled peptide assemblies by molecular design." J.Am.Chem.Soc. doi:10.1021/jacs.0c04203


Damakoudi, V.,  T. Feldner, E. Dilji, A. Belkin and C. Richert (2020). "Hybridization Networks of mRNA and Branched RNA Hybrids." ChemBioChem. doi:10.1002/cbic.202000678

nature communications

Donau, C.,  F. Späth, M. Sosson, B.A.K. Kriebisch, F. Schnitter, M. Tena-Solsona, H.-S. Kang, E. Salibi, M. Sattler, H. Mutschler and J. Boekhoven (2020). "Active Coacervate Droplets as a Model for Membraneless Organelles and Protocells." Nat Commun. doi:10.1038/s41467-020-18815-9


Frank, T.,  K. Vogele, A. Dupin, F.C. Simmel and T. Pirzer (2020). "Growth of giant peptide vesicles driven by compartmentalized transcription‐translation activity." Chem. Eur. J. doi:10.1002/chem.202003366


Haas, M.,  S. Lamour, S.B. Christ and O. Trapp (2020). "Mineral-mediated carbohydrate synthesis by mechanical forces in a primordial geochemical setting." Communications Chemistry doi:10.1038/s42004-020-00387-w


Jash, B and C. Richert (2020). "Templates direct the sequence-specific anchoring of the C-terminus of peptido RNAs." Chemical Science. doi:10.1039/C9SC05958J


Jovanovic, D.,  P. Tremmel, P. S. Pallan, M. Egli and C. Richert (2020). "The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid." Angew Chem Int Ed Engl. doi:10.1002/anie.202008665


Kriebisch, Brigitte A. K. , A. Jussupow, A. M. Bergmann, F. Kohler, H. Dietz, V. R. I. Kaila, and J. Boekhoven (2020). "Reciprocal Coupling in Chemically Fueled Assembly: A Reaction Cycle Regulates Self-Assembly and Vice Versa." J. Am. Chem. Soc. doi:10.1021/jacs.0c10486


Kruse, F.,  J. Teichert and O. Trapp (2020). "Prebiotic Nucleoside Synthesis - The Selectivity of Simplicity." Chem. Eur. J. doi:10.1002/chem.202001513


Le Vay, K., E. Salibi, E.Y. Song and H. Mutschler (2020). "Nucleic Acid Catalysis Under Potential Prebiotic Conditions." Chem. Asian J. doi:10.1002/asia.201901205

Nucleic Acids Research

Motsch, S., P. Tremmel and C. Richert (2020). "Regioselective formation of RNA strands in the absence of magnesium ions." Nucleic Acids Res. doi:10.1093/nar/gkz1125


Orsi, W. D., B. Schink, W. Buckel and W. F. Martin (2020). "Physiological limits to life in anoxic subseafloorsediment." FEMS Microbiol Rev. doi:10.1093/femsre/fuaa004


Preiner M., S. Asche, S. Becker, H.C. Betts, A. Boniface, E. Camprubi, K. Chandru, V. Erastova, S.G. Garg, N. Khawaja, G. Kostyrka, R. Machné, G. Moggioli, K.B. Muchowska, S. Neukirchen, B. Peter, E. Pichlhöfer, Á. Radványi , D. Rossetto, A. Salditt, N.M. Schmelling, F.L. Sousa, F.D.K Tria, D. Vörös, J.C. Xavier (2020). "The Future of Origin of Life Research: Bridging Decades-Old Divisions." Life. doi:10.3390/life10030020


Räuchle, M., G. Leveau and C. Richert (2020). "Synthesis of Peptido RNAs from Unprotected Peptides and Oligoribonucleotides via Coupling in Aqueous Solution." Eur. J. Org. Chem. doi:10.1002/ejoc.202000929

j co2 utilization

Romero Cuellar, N.S., C. Scherer, B. Kaçkar, W. Eisenreich, C. Huber, K. Wiesner-Fleischer, M. Fleischer and O. Hinrichsen (2020). "Two-step electrochemical reduction of CO2 towards multi-carbon products at high current densities." Journal of CO2 Utilization. doi:10.1016/j.jcou.2019.10.016">

physical review letters

Salditt, A., L.M. R. Keil, D. P. Horning, C. B. Mast, G. F. Joyce, and D. Braun (2020). "Thermal Habitat for RNA Amplification and Accumulation." Phys. Rev. Lett. doi:10.1103/PhysTevLett.125.048104


Sauer, F., C. Sydow and O. Trapp (2020). "A robust sheath-flow CE-MS interface for hyphenation with orbitrap MS." Electrophoresis. doi:10.1002/elps.202000044

nature communications

Schuller, J.M., P. Saura, J. Thiemann, S.K. Schuller, A.P. Gamiz-Hernandez, G. Kurisu, M.M. Nowaczyk and V.R.I. Kaila (2020). "Redox-coupled proton pumping drives carbonconcentration in the photosynthetic complex I." Nat Commun. doi:10.1038/s41467-020-14347-4


Sobotta, J., T. Geisberger, C. Moosmann, C.M. Scheidler, W. Eisenreich, G. Wächtershäuser and C. Huber (2020). "A Possible Primordial Acetyleno/Carboxydotrophic Core Metabolism." Life. doi:10.3390/life10040035


Song, E.Y., E.I. Jiménez, H. Lin, K. Le Vay, R. Krishnamurthy and H. Mutschler (2020). "Prebiotically plausible RNA activation compatible with ribozyme‐catalyzed ligation." Angew Chem Int Ed Engl. doi:10.1002/anie.202010918


Spona-Friedl, M., A. Braun, C. Huber, W. Eisenreich, C. Griebler, A. Kappler and M. Elsner (2020). "Substrate-dependent CO2-fixation in heterotrophic bacteria revealed by stable isotope labelling." FEMS Microbiology Ecology. doi:10.1093/femsec/fiaa080


Tena-Solsona, M., J. Janssen, C. Wanzke, F. Schnitter, H. Park, B. Rieß, J. M. Gibbs, C. A. Weber and J. Boekhoven (2020). "Accelerated Ripening in Chemically Fueled Emulsions." ChemSystemsChem. doi:10.1002/syst.202000034


Trapp, O. (2020). "Efficient Amplification in Soai's Asymmetric Autocatalysis by a Transient Stereodynamic Catalyst." Front. Chem. doi:10.3389/fchem.2020.615800

materials horizons

Wanzke, C., M. Tena-Solsona, B. Rieß, L. Tebcharania and J. Boekhoven (2020). "Active droplets in a hydrogel release drugs with a constant and tunable rate." Mater.Horiz. doi:10.1039/C9MH01822K


Winkler, M., B.M. Giuliano, and P. Caselli (2020). "UV Resistance of Nucleosides—An Experimental Approach." ACS Earth Space Chem. doi:10.1021/acsearthspacechem.0c00228



chemical science

Edeleva, E., A. Salditt, J. D. Stamp, P. Schwintek, J. Boekhoven and D. Braun (2019). "Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides." Chemical Science. doi:10.1039/C9SC00770A


Geisberger, T., P. Diederich, T. Steiner, W. Eisenreich, P. Schmitt-Kopplin and C. Huber (2019). "Evolutionary Steps in the Analytics of Primordial Metabolic Evolution." Life (Basel) 9(2). doi:10.3390/life9020050


Grötsch, R. K., C. Wanzke, M. Speckbacher, A. Angı, B. Rieger and J. Boekhoven (2019). "Pathway Dependence in the Fuel-Driven Dissipative Self-Assembly of Nanoparticles." J. Am. Chem. Soc. doi:10.1021/jacs.9b02004

scientific reports

Kudella, P. W., K. Preißinger, M. Morasch, C. F. Dirscherl, D. Braun, A. Wixforth and C. Westerhausen (2019). "Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection." Scientific Reports. doi:10.1038/s41598-019-55110-0


Lamour, S., S. Pallmann, M. Haas and O. Trapp (2019). "Prebiotic Sugar Formation Under Nonaqueous Conditions and Mechanochemical Acceleration." Life (Basel) 9(2). doi:10.3390/life9020052

nature chemistry

Morasch, M., J. Liu, C. F. Dirscherl, A. Ianeselli, A. Kuhnlein, K. Le Vay, P. Schwintek, S. Islam, M. K. Corpinot, B. Scheu, D. B. Dingwell, P. Schwille, H. Mutschler, M. W. Powner, C. B. Mast and D. Braun (2019). "Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules." Nat Chem. doi:10.1038/s41557-019-0299-5

Nucleic Acids Research

Sosson, M., D. Pfeffer and C. Richert (2019). "Enzyme-free ligation of dimers and trimers to RNA primers." Nucleic Acids Res. doi:10.1093/nar/gkz160

geophysical research letters

Stern, S., C. Cimarelli, D. Gaudin, B.Scheu and D.B. Dingwell (2019). "Electrification of experimental volcanic jets with varying water content and temperature." Geophysical Research Letters. doi:10.1029/2019GL084678


Teichert, J., F. Kruse and O. Trapp (2019). "Direct Prebiotic Pathway to DNA Nucleosides." Angewandte Chemie International Edition. doi:10.1002/anie.201903400

israel journal of chemistry

Tena-Solsona, M. and J. Boekhoven (2019). "Dissipative Self-Assembly of Peptides." Israel Journal of Chemistry. doi:10.1002/ijch.201900018 

physical review x

Toyabe, S. and D. Braun (2019). "Cooperative Ligation Breaks Sequence Symmetry and Stabilizes Early Molecular Replication." Physical Review X 9(1): 011056. doi:10.1103/PhysRevX.9.011056


Vogele, K., T. Pirzer and F.C. Simmel (2019). "Genetically Encoded Membranes for Bottom‐Up Biology." ChemSystemsChem. doi:10.1002/syst.20100016


Wanzke, C., A. Jussupow, F. Kohler, H. Dietz, V.R.I. Kaila and J. Boekhoven (2019). "Dynamic vesicles formed by dissipative self-assembly." ChemSystemsChem. doi:10.1002/syst.201900044



physical review e

Möller, F. M., M. Kieß, C. Mast and D. Braun (2018). "Optochemical disequilibrium to measure biomolecule charge." Physical Review E 98(6): 062601. doi:10.1103/PhysRevE.98.062601