CRC 235 Emergence of Life

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Bartolucci, G., A. Calaça Serrão, P. Schwintek, A. Kühnlein, Y. Rana, P. Janto, D. Hofer, C.B. Mast, D. Braun, C.A. Weber (2023) "Sequence self-selection by cyclic phase separation." PNAS. doi:10.1073/pnas.2218876120


Bechtel, M., M. Ebeling, L. Huber and O. Trapp (2023). "(Photoredox) Organocatalysis in the Emergence of Life: Discovery, Applications, and Molecular Evolution." Acc. Chem. Res. doi:10.1021/acs.accounts.3c00396


Calaça Serrão, A., S. Wunnava, A.V. Dass, L. Ufer, P. Schwintek, C.B. Mast, D. Braun (2023). "High-Fidelity Templated Ligation of RNA via 2′,3′-cyclic Phosphate." ChemRxiv. doi:10.26434/chemrxiv-2023-m261p


Çalışkanoğlu, A.Z.,  D.B. Dingwell, C. Cimarelli, A.S.B. Camara, H. Breitzke, G. Buntkowsky, M.A. Pasek, D. Braun, B. Scheu, K. Molaverdikhani (2023). "Reactive phosphorus via simulated lightning discharge: A role for fulgurites in pre-biotic chemistry." Chem. Geo. doi:10.1016/j.chemgeo.2023.1213439

chemical science

Chen, X., B.A.K. Kriebisch, A.M. Bergmann, and J. Boekhoven (2023). "Design rules for reciprocal coupling in chemically fueled assembly" Chemical Science. doi:10.1039/d3sc02062b


Coskun, Ö.K., G.V. Gomez-Saez, M. Beren, G. Ozcan, H. Hosgormez, F. Einseidl, and W.D. Orsi (2023). "Carbon metabolism and biogeography of candidate phylum "Candidatus Bipolaricaulota" in geothermal environments of Biga Peninsula, Turkey" Frontiers in Microbiology. doi:10.3389/fmicb.2023.1063139


Diederich, P., T. Geisberger, Y. Yan, C. Seitz, A. Ruf, C. Huber, N. Hertkorn and P. Schmitt-Kopplin (2023) "Formation, stabilization and fate of acetaldehyde and higher aldehydes in an autonomously changing prebiotic system emerging from acetylene." Commun Chem doi:10.1038/s42004-023-00833-5


Diederich, P., A. Ruf, T. Geisberger, L. Weidner, C. Seitz, W. Eisenreich, C. Huber, and P. Schmitt-Kopplin (2023) "C2-addition patterns emerging from acetylene and nickel sulfide in simulated prebiotic hydrothermal conditions." Commun Chem doi:10.1038/s42004-023-01021-1


Dirscherl, C. F. , A. Ianeselli, D. Tetiker, T. Matreux, R. M. Queener, C. B. Mast and D. Braun (2023) "A heated rock crack captures and polymerizes primordial DNA and RNA." Phys. Chem. Chem Phys. doi:10.1039/D2CP04538A

scientific reports

Geisberger, T., P. Diederich, C.J.O. Kaiser, K. Vogele, A. Ruf, C. Seitz, F. Simmel, W. Eisenreich, P. Schmitt-Kopplin and C. Huber (2023) Formation of vesicular structures from fatty acids formed under simulated volcanic hydrothermal conditions. Sci Rep 13, 15227. doi:10.1038/s41598-023-42552-w


Helmbrecht, V., M. Weingart, F. Klein, D. Braun and W.D. Orsi (2023) "White and green rust chimneys accumulate RNA in a ferruginous chemical garden." Geobiology. doi:10.1111/gbi.12572

nature reviews physics

Ianeselli, A., A. Salditt, C. Mast, B. Ercolano, C. L. Kufner, B. Scheu & D. Braun (2023) "Physical non-equilibria for prebiotic nucleic acid chemistry." Nature Reviews Physics. doi:10.1038/s42254-022-00550-3


Kriebisch, C., L. Burger, O. Zozulia, M. Stasi, A. Floroni, D. Braun, U. Gerland & J. Boekhoven (2023) "Template-based information transfer in chemically fueled dynamic combinatorial libraries." Research Square. doi:10.21203/


Kufner, C. L., S. Krebs, M. Fischaleck, J. Philippou-Massier, H. Blum, D. B. Bucher, D. Braun, W. Zinth & C. Mast (2023) "Sequence dependent UV damage of complete pools of oligonucleotides." Sci Rep. doi:10.1038/s41598-023-29833-0


Laurent, G., T. Göppel, D. Lacoste, & U. Gerland (2023) "Emergence of homochirality via template-directed ligation in an RNA reactor." arXiv. doi:10.48550/arXiv.2311.04677


Le Vay, K. K., E. Salibi, B. Ghosh, T-Y. D. Tan, H. Mutschler (2023) "Ribozyme activity modulates the physical properties of RNA-peptide coacervates." eLife.  doi:10.7554/eLife.83543


Matreux, T., B. Altaner, J. Raith, D. Braun, C. Mast & U. Gerland (2023) "Formation mechanism of thermally controlled pH gradients." Communications Physics. doi:10.1038/s42005-023-01126-y

physical review letters

Mayer, D.B., T. Franosch, C. Mast &  D. Braun (2023) "Thermophoresis beyond Local Thermodynamic Equilibrium." Phys. Rev. Lett. doi:10.1038/10.1103/PhysRevLett.130.168202


Peter, B., A. Levrier & P. Schwille (2023) "Spatiotemporal Propagation of a Minimal Catalytic RNA Network in GUV Protocells by Temperature Cycling and Phase Separation." Angew. Chem. Int. Ed. doi:10.1002/anie.202218507


Peter, B. & P. Schwille (2023) "Elucidating the Mechanism of Freeze-Thaw Driven ContentMixing Between Protocells." ChemSystemsChem doi:10.1002/syst.202300008

scientific reports

Peters, S., D.A. Semenov, R. Hochleitner  & O. Trapp (2023) "Synthesis of prebiotic organics from CO2 by catalysis with meteoritic and volcanic particles." Scientific Reports doi:10.1038/s41598-023-33741-8

nature communications

Salditt A., L. Karr, E. Salibi, K. Le Vay, D. Braun and H. Mutschler (2023). "Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment." Nature Communications. doi: 10.1038/s41467-023-37206-4

nature communications

Salibi, Elia., B. Peter, P. Schwille, and H. Mutschler (2023). "Periodic temperature changes drive the proliferation of self-replicating RNAs in vesicle populations." Nature Communications. doi:10.1038/s41467-023-36940-z

nature communications

Schmitt-Kopplin, P. , N. Hertkorn, M. Harir (2023). "Molecular atlas of Ryugu reveals cold hydrothermalism on C-type asteroid parent body." Nature Communications. doi:10.1038/s41467-023-42075-y


Schmitt-Kopplin, P. , M. Matzka, A. Ruf, B. Menez, H. C. Aoudjehane, M. Harir, M. Lucio, J. Hertzog, N. Hertkorn, R. D. Gougeon, V. Hoffmann, N. W. Hinman, L. Ferrière, A. Greshake, Z. Gabelica, L. Trif, and A. Steele (2023). "Complex carbonaceous matter in Tissint martian meteorites give insights into the diversity of organic geochemistry on Mars." Science Advances. doi:10.1126/sciadv.add6439


Serra, C. , V. Vinogradoff, P. Poinot, Q. Blancart Remaury, F. Duvernay, L. Le Sergeant d'Hendecourt, G. Danger, P. Claeys, S. Goderis, and P. Schmitt-Kopplin (2023). "Assessing the Effect of Aqueous Alteration on Soluble Organic Matter in Primitive Carbonaceous Chondrites: The Case of Asuka 12236." ACS Earth Space Chem. doi:10.1021/acsearthspacechem.3c00106


Sponer, J.E., J. Klouzek, J. Vyravsky, S. Wunnava, B. Scheu, D. Braun, S.J. Mojzsis, J. Palacky, M. Vorlickova, J. Sponer, R. Matyasek, and A. Kovarik (2023). "Influence of Silicate Rock Glass Compositions on the Efficacy of Prebiotic RNA Polymerization Reactions: The Case of 3’,5’ Cyclic Guanosine Monophosphate." ChemSystemsChem. doi:10.1002/syst.202300016


Springsklee, C., B. Scheu, C. Seifert, M. Manga, C. Cimarelli, D. Gaudin, O. Trapp, and D.B. Dingwell (2023). " A gas-tight shock tube apparatus for laboratory volcanic lightning under varying atmospheric conditions." Volcanica. doi:10.30909/vol.06.02.437445


Su, M. , C. Schmitt, Z. Liu, BS. J. Roberts, K. C. Liu, K. Röder, A. Jäschke, D. J. Wales, J. D. Sutherland (2023). "Triplet-encoded prebiotic RNA aminoacylation." J. Am. Chem. Soc. doi:10.1021/jacs.3c03931


Weingart, M. , S. Chen, C. Donat, V. Helmbrecht, W. D. Orsi, D. Braun, K. Alim (2023). "Alkaline Vents Recreated in Two Dimensions to Study pH Gradients, Precipitation Morphology and Molecule Accumulation." Science Advances, accepted. Preprint is available at arXiv  doi:10.48550/arXiv.2303.10156


Welsch, F., E. Kervio, P. Tremmel, C. Richert (2023). "Prolinyl Nucleotides Drive Enzyme-Free Genetic Copying of RNA." Angew. Chem. Int. Ed. doi:10.1002/anie.202307591


Wienand, K. , L. Kampschulte, and W. M. Heckl (2023). "Creating a foundation for origin of life
outreach: How scientists relate to their field, the public, and religion." PLoS ONE. doi:10.1371/journal.pone.0282243




Bechtel, M., E. Hümmer, O. Trapp (2022) "Selective phosphorylation of RNA- and DNA-nucleosides under prebiotically plausible conditions." ChemSystemsChem. doi: 10.1002/syst.202200020


Bremer J., C. Richter, H. Schwalbe, C. Richert (2022) "Synthesis of a Peptidoyl RNA Hairpin via a Combination of Solid-Phase and Template-Directed Chain Assembly." ChemBioChem. doi: 10.1002/cbic.202200352


Danger G., A. Ruf, T. Javelle, J. Maillard, V. Vinogradoff, C. Afonso, I. Schmitz-Afonso, L. Remusat, Z. Gabelica, P. Schmitt-Kopplin (2022) "The transition from soluble to insoluble organic matter in
interstellar ice analogs and meteorites." Astronomy & Astrophysics. doi: 10.1051/0004-6361/202244191


Dass A.V., S. Wunnava, J. Langlais, B. von der Esch, M. Krusche, L. Ufer, N. Chrisam, R.C.A. Dubini, F. Gartner, S. Angerpointner, C.F. Dirscherl, P. Rovó, C.B. Mast, J.E. Sponer, C. Ochsenfeld, E. Frey and D. Braun (2022) "RNA polymerisation without added catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces." ChemSystemsChem. doi: 10.1002/syst.202200026


Donau C. and J. Boekhoven (2022) "The chemistry of chemically fueled droplets." Trends in Chem. doi: 10.1016/j.trechm.2022.11.003


Donau C., F. Späth, M. Stasi, A.M. Bergmann and J. Boekhoven (2022) "Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets." Angew. Chem. Int. Ed. doi: 10.1002/anie.202211905


Doppleb, O. , R.J. Schwarz, M. Landa, C. Richert (2022) "Efficient oligomerization of aromatic amino acids induced by gaps in four-helix bundles of DNA or RNA." Chem. Eur. J. doi: 10.1002/chem.202104104


Emslander, Q., K. Vogele, P. Braun, J. Stender, C. Willy, M. Joppich, J.A. Hammer, M. Abele, C. Meng, A. Pichlmair, C. Ludwig, J.J. Bugert, F.C. Simmel, G.G. Westmeyer (2022) "Cell-free production of personalized therapeutic phages targeting multidrug-resistant bacteria." Cell Chemical Biology doi: 10.1016/j.chembiol.2022.06.003


Gartner, F. M., I. R. Graf, and E. Frey (2022). "The Time Complexity of Self-Assembly." PNAS. doi:10.1073/pnas.2116373119


Göppel , T., J. H. Rosenberger, B. Altaner, and U. Gerland (2022). "Thermodynamic and Kinetic Sequence Selection in Enzyme-Free Polymer Self-Assembly inside a Non-equilibrium RNA Reactor." Life. doi: 10.3390/life12040567


Grosch, M., M.T. Stiebritz, R. Bolney, M. Winkler, E. Jückstock, H. Busch, S. Peters, A.F.  Siegle, J. van Slageren, M. Ribbe, Y. Hu, O. Trapp, C. Robl,  and W. Weigand (2022). "Mackinawite supported reduction of C1 substrates into prebiotically relevant precursors." ChemSystemsChem. doi:10.1002/syst.202200010

org life evo biosph

Huber, L., and O. Trapp (2022). "Symmetry Breaking by Consecutive Amplification: Efficient Paths to Homochirality." Orig Life Evol Biosph. doi:10.1007/s11084-022-09627-6

nature physics

Ianeselli, A., M. Atienza, P. W. Kudella, U. Gerland, C. B. Mast, and D. Braun (2022). "Water cycles in a Hadean CO2 atmosphere drive the evolution of long DNA." Nat. Phys.  doi:10.1038/s41567-022-01516-z


Jones, T. J., K. V. Cashman, E. J. Liu, A. C. Rust and B. Scheu (2022). "Magma fragmentation: a perspective on emerging topics and future directions." Bulletin of Volcanology 84(5): 45. doi:10.1007/s00445-022-01555-7

physical review letters

Katzmeier, F., B. Altaner, J. List, U. Gerland, and F. C. Simmel (2022). "Emergence of colloidal patterns in AC electrical fields ." Phys. Rev. Lett. doi: 10.1103/PhysRevLett.128.058002


Leveau, G., D. Pfeffer, B. Altaner, E. Kervio, F. Welsch, U. Gerland, and C. Richert (2022). "Enzyme-Free Copying of 12Bases of RNA with Dinucleotides." Angew. Chem. Int. Ed. doi: 10.1002/anie.202203067

rev in min geochem

Scheu, B., and D. B. Dingwell (2022). "Magma Fragmentation." Reviews in Mineralogy and Geochemistry. doi: 10.2138/rmg.2021.87.16


Springsklee C., M. Manga, B. Scheu, C. Cimarelli and D. B. Dingwell (2022). "Electric Discharge in Erupting Mud." Geophysical Research Letters. doi: 10.1029/2022GL100852

jgr solid earth

Springsklee C., B. Scheu, M. Manga, V. Cigala, C. Cimarelli and D. B. Dingwell (2022). "The Influence of Grain Size Distribution on Laboratory-Generated Volcanic Lightning." Journal of Geophysical Research: Solid Earth. doi: 10.1029/2022JB024390


Stan, A., B. von der Esch and C. Ochsenfeld (2022). "Fully Automated Generation of Prebiotically Relevant Reaction Networks from Optimized Nanoreactor Simulations." J.Chem. Theory Comput. doi: 10.1021/acs.jctc.2c00754


Steffens, L., E. Pettinato, T.M. Steiner, W. Eisenreich and I.A. Berg (2022). "Tracking the reversed oxidative tricarboxylic acid cycle in bacteria." Bio-protocol. doi: 10.21769/BioProtoc.4364


Sydow C., F. Sauer, A. F. Siegle, and O. Trapp (2022) "Iron-mediated peptide formation in water and liquid sulfur dioxide under prebiotically plausible conditions." ChemSystemsChem. doi: 10.1002/syst.202200034


Tekin E., A. Salditt, P. Schwintek, S. Wunnava, J. Langlais, J. Saenz, D. Tang, P. Schwille, C. Mast and D. Braun (2022) "Prebiotic foam environments to oligomerize and accumulate RNA." ChemBioChem. doi: 10.1002/cbic.202200423




Closs, A., Bechtel, M. and Trapp, O. (2021) "Dynamic Exchange of Substituents in a Prebiotic Organocatalyst: Initial Steps towards an Evolutionary System." Angew. Chem. Int. Ed. doi:10.1002/anie.202112563


Colombier, M., J. Vasseur, B.F. Houghton, F. Cáceres, B. Scheu, U. Kueppers, S. Thivet, L. Gurioli, C. Montanaro, A. Soldati, A. Di Muro, D.B. Dingwell (2021) "Degassing and gas percolation in basaltic magmas." Earth and Planetary Science Letters. doi:10.1016/j.epsl.2021.117134


Coskun, Ö.K., Vuillemin, A., Schubotz, F., Klein, F., Sichel, S.E., Eisenreich, W., and Orsi, W.D. (2021) "Quantifying the effects of hydrogen on carbon assimilation in a seafloor microbial community associated with ultramafic rocks." ISME J. doi:10.1038/s41396-021-01066-x

nature communications

Danger, G., V. Vinogradoff, M. Matzka, J-C. Viennet, L. Remusat, S. Bernard, A. Ruf, L. Le Sergeant d’Hendecourt, P. Schmitt-Kopplin (2021). "Exploring the link between molecular cloud ices and chondritic organic matter in laboratory." Nature Communications. doi:10.1038/s41467-021-23895-2


Doppleb, O., Bremer, J., Bechthold, M., Sánchez Rico, C., Göhringer, D., Griesser, H. and Richert, C. (2021) "Determining the Diastereoselectivity of the Formation of Dipeptidonucleotides by NMR Spectroscopy." Chem. Eur. J. doi:10.1002/chem.202101630

2021_von der esch

Esch, B. v. d., L.D.M. Peters, L. Sauerland, C. Ochsenfeld (2021). "Quantitative Comparison of Experimental and Computed IR-Spectra Extracted from Ab Initio Molecular Dynamics." J. Chem. Theory Comput. doi:10.1021/acs.jctc.0c01279


Falgenhauer E., S. von Schönberg, C. Meng, A. Mückl, K. Vogele, Q. Emslander, C. Ludwig, F.C. Simmel (2021). "Evaluation of an E. coli cell extract prepared by lysozyme-assisted sonication via gene expression, phage assembly and proteomics." Chembiochem.
doi: 10.1002/cbic.202100257


Geisberger, T., J. Sobotta, W. Eisenreich, and C. Huber (2021). "Formation of Thiophene under Simulated Volcanic Hydrothermal Conditions on Earth - Implications for Early Life on Extraterrestrial Planets? ." Life. doi:10.3390/life11020149


Han, J., Kervio, E., and Richert, C. (2021) "High fidelity enzyme-free primer extension with an ethynylpyridone thymidine analog." Chem. Eur. J. doi:10.1002/chem.202102996


Ianeselli A., D. Tetiker, J. Stein, A. Kühnlein, C. B. Mast, D. Braun, and T.-Y. D. Tang (2021) "Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells." Nat. Chem. doi:10.1038/s41557-021-00830-y


Jash, B., Tremmel, P., Jovanovic, D., and Richert, C. (2021) "Single nucleotide translation without ribosomes." Nat. Chem. doi:10.1038/s41557-021-00749-4


Kriebisch, C.M.E., A. Bergmann, and J. Boekhoven (2021). "Fuel-Driven Dynamic Combinatorial Libraries ." J. Am. Chem. Soc. doi:110.1021/jacs.1c01616


Kudella, P., A.V. Tkachenko, A. Salditt, S. Maslov, and D. Braun (2021). "Structured sequences emerge from random pool when replicated by templated ligation." PNAS. doi:10.1073/pnas.2018830118


Kunze, M., T. Steiner, F. Chen, C. Huber, K. Rydzewski, M. Stämmler, K. Heuner and W. Eisenreich (2021). "Metabolic adaption of Legionella pneumophila during intracellular growth in Acanthamoeba castellanii." IJMM. doi:10.1016/j.ijmm.2021.151504


Kühnlein, A., S.A. Lanzmich, and D. Braun (2021). "tRNA sequences can assemble into areplicator." eLife. doi:10.7554/eLife.63431


Le Vay, K.K., E.Y. Song, B. Ghosh, D. Tang and H. Mutschler (2021). "Enhanced ribozyme-catalyzed recombination and oligonucleotide assembly in peptide-RNA condensates." Angew. Chem. Int. Ed. doi:10.1002/anie.202109267


Matreux, T., K. LeVay, A. Schmid, P. Aikkila, L. Belohlavek, A. Z. Çalışkanoğlu, E. Salibi,
A. Kühnlein, C. Springsklee, B. Scheu, D. B. Dingwell, D. Braun, H. Mutschler and
C. B. Mast (2021). "Heat flows in rock cracks naturally optimize
salt compositions for ribozymes." Nat. Chem. doi:10.1038/s41557-021-00772-5


Matzka, M., M. Lucio, B. Kanawati, E. Quirico, L. Bonal, S. Loehle, and P. Schmitt-Kopplin (2021). "Thermal History of Asteroid Parent Bodies Is Reflected in Their Metalorganic Chemistry." The Astrophysical Journal Letters. doi:10.3847/2041-8213/ac0727


Mühlbauer, M. E., A. P. Gamiz-Hernandez, and V. R. I. Kaila (2021). "Functional Dynamics of an Ancient Membrane-Bound Hydrogenase." J. Am. Chem. Soc. doi:10.1021/jacs.1c09356

marine geo

Puzenat, V., J. Escartin, J.-E. Martelat, T. Barreyre, S. Le Moine Bauer,  P. Nomikou, N. Gracias, P. Allemand, V. Antoniou, O. Coskun, R. Garcia, P. Grandjean, S.L. Jørgensen, L. Magíf, M. Mandalakis, W. Orsi, P. Polymenakou, A. Schouw, G. Vallicrosa, O. Vlasopoulos (2021). "Shallow-water hydrothermalism at Milos (Greece): Nature, distribution, heat fluxes and impact on ecosystems." Marine Geology. doi:10.1016/j.margeo.2021.106521

physical review x

Rosenberger, J.H., T. Göppel, P.W. Kudella, D. Braun, U. Gerland, and B. Altaner (2021). "Self-assembly of informational polymers by templated ligation ." Physical Review X. doi:10.1103/PhysRevX.11.031055

nature communications

Sauer, F., M. Haas, C. Sydow, A.F. Sigle, C.A. Lauer, and O. Trapp (2021). "From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth." Nature Communications. doi:10.1038/s41467-021-27527-7

chemical science

Schwarz, P., S. Laha, J. Janssen, T. Huss, J. Boekhoven and C. Weber (2021). "Parasitic Behavior in Competing Chemically Fueled Reaction Cycles ." Chemical Science. doi:10.1039/D1SC01106E


Seitz, C., W. Eisenreich, and C. Huber (2021). "The Abiotic Formation of Pyrrole under Volcanic, Hydrothermal Conditions—An Initial Step towards Life’s First Breath?." Life. doi:10.3390/life11090980


 Späth, F., C. Donau, A.M. Bergmann, M. Kränzlein, C.V. Synatschke, B. Rieger and J. Boekhoven (2021). "Molecular Design of Chemically Fueled Peptide–Polyelectrolyte Coacervate-Based Assemblies." JACS. doi:10.1021/jacs.1c01148


 Šponer, J.E., J. Šponer, J. Výravský, O. Šedo, Z. Zdráhal, G. Costanzo, E. Di Mauro, S. Wunnava, D. Braun, R. Matyášek, and A. Kovařík (2021). "Non-Enzymatic, Template-Free Polymerization of 3’,5’ Cyclic Guanosine Monophosphate on Mineral Surfaces." ChemSystemsChem. doi:10.1002/syst.202100017


 Steffens, L., E. Pettinato, T.M. Steiner, A. Mall, S. König, W Eisenreich, and I.A. Berg (2021). "High CO2 levels drive the TCA cycle backwards towards autotrophy." Nature doi:10.1038/s41586-021-03456-9


 Stein, J.A.C., A. Ianeselli, and D. Braun (2021). "Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics." Angew. Chem.Int.Ed. doi:10.1002/anie.202101261


 Steiner, T.M., C. Lettl, F. Schindele, W. Goebel, R. Haas, W. Fischer and W. Eisenreich (2021). "Substrate usage determines carbon flux via the citrate cycle in Helicobacter pylori." Molecular Microbiology doi:10.1111/mmi.14775


Vogele, K., E. Falgenhauer, S. von Schönberg, F.C. Simmel and T. Pirzer (2021). "Small Antisense DNA-Based Gene Silencing Enables Cell-Free Bacteriophage Manipulation and Genome Replication." ACS Synth. Biol. doi:10.1021/acssynbio.0c00402


Wunnava, S., Dirscherl, C..F., Výravský, J., Kovařík, A., Matyášek, R., Šponer, J., Braun, D. and Šponer, J..E. (2021). "Acid-catalyzed RNA-oligomerization from 3´,5´-cGMP." Chem. Eur. J. doi:10.1002/chem.202103672




Closs, A.C., E. Fuks, M. Bechtel and O. Trapp (2020). "Prebiotically plausible organocatalysts enabling a selective photoredox α‐alkylation of aldehydes on the Early Earth." Chem. Eur. J. doi:10.1002/chem.202001514


Dai, K.,  J. R. Fores, C. Wanzke, B. Winkeljann, A. M. Bergmann, O. Lieleg, and J. Boekhoven (2020). "Regulating chemically fueled peptide assemblies by molecular design." J.Am.Chem.Soc. doi:10.1021/jacs.0c04203


Damakoudi, V.,  T. Feldner, E. Dilji, A. Belkin and C. Richert (2020). "Hybridization Networks of mRNA and Branched RNA Hybrids." ChemBioChem. doi:10.1002/cbic.202000678

nature communications

Donau, C.,  F. Späth, M. Sosson, B.A.K. Kriebisch, F. Schnitter, M. Tena-Solsona, H.-S. Kang, E. Salibi, M. Sattler, H. Mutschler and J. Boekhoven (2020). "Active Coacervate Droplets as a Model for Membraneless Organelles and Protocells." Nat Commun. doi:10.1038/s41467-020-18815-9


Frank, T.,  K. Vogele, A. Dupin, F.C. Simmel and T. Pirzer (2020). "Growth of giant peptide vesicles driven by compartmentalized transcription‐translation activity." Chem. Eur. J. doi:10.1002/chem.202003366


Haas, M.,  S. Lamour, S.B. Christ and O. Trapp (2020). "Mineral-mediated carbohydrate synthesis by mechanical forces in a primordial geochemical setting." Communications Chemistry doi:10.1038/s42004-020-00387-w


Jash, B and C. Richert (2020). "Templates direct the sequence-specific anchoring of the C-terminus of peptido RNAs." Chemical Science. doi:10.1039/C9SC05958J


Jovanovic, D.,  P. Tremmel, P. S. Pallan, M. Egli and C. Richert (2020). "The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid." Angew Chem Int Ed Engl. doi:10.1002/anie.202008665


Kriebisch, Brigitte A. K. , A. Jussupow, A. M. Bergmann, F. Kohler, H. Dietz, V. R. I. Kaila, and J. Boekhoven (2020). "Reciprocal Coupling in Chemically Fueled Assembly: A Reaction Cycle Regulates Self-Assembly and Vice Versa." J. Am. Chem. Soc. doi:10.1021/jacs.0c10486


Kruse, F.,  J. Teichert and O. Trapp (2020). "Prebiotic Nucleoside Synthesis - The Selectivity of Simplicity." Chem. Eur. J. doi:10.1002/chem.202001513


Le Vay, K., E. Salibi, E.Y. Song and H. Mutschler (2020). "Nucleic Acid Catalysis Under Potential Prebiotic Conditions." Chem. Asian J. doi:10.1002/asia.201901205

Nucleic Acids Research

Motsch, S., P. Tremmel and C. Richert (2020). "Regioselective formation of RNA strands in the absence of magnesium ions." Nucleic Acids Res. doi:10.1093/nar/gkz1125


Orsi, W. D., B. Schink, W. Buckel and W. F. Martin (2020). "Physiological limits to life in anoxic subseafloorsediment." FEMS Microbiol Rev. doi:10.1093/femsre/fuaa004


Preiner M., S. Asche, S. Becker, H.C. Betts, A. Boniface, E. Camprubi, K. Chandru, V. Erastova, S.G. Garg, N. Khawaja, G. Kostyrka, R. Machné, G. Moggioli, K.B. Muchowska, S. Neukirchen, B. Peter, E. Pichlhöfer, Á. Radványi , D. Rossetto, A. Salditt, N.M. Schmelling, F.L. Sousa, F.D.K Tria, D. Vörös, J.C. Xavier (2020). "The Future of Origin of Life Research: Bridging Decades-Old Divisions." Life. doi:10.3390/life10030020


Räuchle, M., G. Leveau and C. Richert (2020). "Synthesis of Peptido RNAs from Unprotected Peptides and Oligoribonucleotides via Coupling in Aqueous Solution." Eur. J. Org. Chem. doi:10.1002/ejoc.202000929

j co2 utilization

Romero Cuellar, N.S., C. Scherer, B. Kaçkar, W. Eisenreich, C. Huber, K. Wiesner-Fleischer, M. Fleischer and O. Hinrichsen (2020). "Two-step electrochemical reduction of CO2 towards multi-carbon products at high current densities." Journal of CO2 Utilization. doi:10.1016/j.jcou.2019.10.016">

physical review letters

Salditt, A., L.M. R. Keil, D. P. Horning, C. B. Mast, G. F. Joyce, and D. Braun (2020). "Thermal Habitat for RNA Amplification and Accumulation." Phys. Rev. Lett. doi:10.1103/PhysTevLett.125.048104


Sauer, F., C. Sydow and O. Trapp (2020). "A robust sheath-flow CE-MS interface for hyphenation with orbitrap MS." Electrophoresis. doi:10.1002/elps.202000044

nature communications

Schuller, J.M., P. Saura, J. Thiemann, S.K. Schuller, A.P. Gamiz-Hernandez, G. Kurisu, M.M. Nowaczyk and V.R.I. Kaila (2020). "Redox-coupled proton pumping drives carbonconcentration in the photosynthetic complex I." Nat Commun. doi:10.1038/s41467-020-14347-4


Sobotta, J., T. Geisberger, C. Moosmann, C.M. Scheidler, W. Eisenreich, G. Wächtershäuser and C. Huber (2020). "A Possible Primordial Acetyleno/Carboxydotrophic Core Metabolism." Life. doi:10.3390/life10040035


Song, E.Y., E.I. Jiménez, H. Lin, K. Le Vay, R. Krishnamurthy and H. Mutschler (2020). "Prebiotically plausible RNA activation compatible with ribozyme‐catalyzed ligation." Angew Chem Int Ed Engl. doi:10.1002/anie.202010918


Spona-Friedl, M., A. Braun, C. Huber, W. Eisenreich, C. Griebler, A. Kappler and M. Elsner (2020). "Substrate-dependent CO2-fixation in heterotrophic bacteria revealed by stable isotope labelling." FEMS Microbiology Ecology. doi:10.1093/femsec/fiaa080


Tena-Solsona, M., J. Janssen, C. Wanzke, F. Schnitter, H. Park, B. Rieß, J. M. Gibbs, C. A. Weber and J. Boekhoven (2020). "Accelerated Ripening in Chemically Fueled Emulsions." ChemSystemsChem. doi:10.1002/syst.202000034


Trapp, O. (2020). "Efficient Amplification in Soai's Asymmetric Autocatalysis by a Transient Stereodynamic Catalyst." Front. Chem. doi:10.3389/fchem.2020.615800

materials horizons

Wanzke, C., M. Tena-Solsona, B. Rieß, L. Tebcharania and J. Boekhoven (2020). "Active droplets in a hydrogel release drugs with a constant and tunable rate." Mater.Horiz. doi:10.1039/C9MH01822K


Winkler, M., B.M. Giuliano, and P. Caselli (2020). "UV Resistance of Nucleosides—An Experimental Approach." ACS Earth Space Chem. doi:10.1021/acsearthspacechem.0c00228



chemical science

Edeleva, E., A. Salditt, J. D. Stamp, P. Schwintek, J. Boekhoven and D. Braun (2019). "Continuous nonenzymatic cross-replication of DNA strands with in situ activated DNA oligonucleotides." Chemical Science. doi:10.1039/C9SC00770A


Geisberger, T., P. Diederich, T. Steiner, W. Eisenreich, P. Schmitt-Kopplin and C. Huber (2019). "Evolutionary Steps in the Analytics of Primordial Metabolic Evolution." Life (Basel) 9(2). doi:10.3390/life9020050


Grötsch, R. K., C. Wanzke, M. Speckbacher, A. Angı, B. Rieger and J. Boekhoven (2019). "Pathway Dependence in the Fuel-Driven Dissipative Self-Assembly of Nanoparticles." J. Am. Chem. Soc. doi:10.1021/jacs.9b02004

scientific reports

Kudella, P. W., K. Preißinger, M. Morasch, C. F. Dirscherl, D. Braun, A. Wixforth and C. Westerhausen (2019). "Fission of Lipid-Vesicles by Membrane Phase Transitions in Thermal Convection." Scientific Reports. doi:10.1038/s41598-019-55110-0


Lamour, S., S. Pallmann, M. Haas and O. Trapp (2019). "Prebiotic Sugar Formation Under Nonaqueous Conditions and Mechanochemical Acceleration." Life (Basel) 9(2). doi:10.3390/life9020052

nature chemistry

Morasch, M., J. Liu, C. F. Dirscherl, A. Ianeselli, A. Kuhnlein, K. Le Vay, P. Schwintek, S. Islam, M. K. Corpinot, B. Scheu, D. B. Dingwell, P. Schwille, H. Mutschler, M. W. Powner, C. B. Mast and D. Braun (2019). "Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules." Nat Chem. doi:10.1038/s41557-019-0299-5

Nucleic Acids Research

Sosson, M., D. Pfeffer and C. Richert (2019). "Enzyme-free ligation of dimers and trimers to RNA primers." Nucleic Acids Res. doi:10.1093/nar/gkz160

geophysical research letters

Stern, S., C. Cimarelli, D. Gaudin, B.Scheu and D.B. Dingwell (2019). "Electrification of experimental volcanic jets with varying water content and temperature." Geophysical Research Letters. doi:10.1029/2019GL084678


Teichert, J., F. Kruse and O. Trapp (2019). "Direct Prebiotic Pathway to DNA Nucleosides." Angewandte Chemie International Edition. doi:10.1002/anie.201903400

israel journal of chemistry

Tena-Solsona, M. and J. Boekhoven (2019). "Dissipative Self-Assembly of Peptides." Israel Journal of Chemistry. doi:10.1002/ijch.201900018 

physical review x

Toyabe, S. and D. Braun (2019). "Cooperative Ligation Breaks Sequence Symmetry and Stabilizes Early Molecular Replication." Physical Review X 9(1): 011056. doi:10.1103/PhysRevX.9.011056


Vogele, K., T. Pirzer and F.C. Simmel (2019). "Genetically Encoded Membranes for Bottom‐Up Biology." ChemSystemsChem. doi:10.1002/syst.20100016


Wanzke, C., A. Jussupow, F. Kohler, H. Dietz, V.R.I. Kaila and J. Boekhoven (2019). "Dynamic vesicles formed by dissipative self-assembly." ChemSystemsChem. doi:10.1002/syst.201900044



physical review e

Möller, F. M., M. Kieß, C. Mast and D. Braun (2018). "Optochemical disequilibrium to measure biomolecule charge." Physical Review E 98(6): 062601. doi:10.1103/PhysRevE.98.062601