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Dynamic vesicles formed by dissipative self-assembly

C. Wanzke et.al. 2019 ChemSystemsChem http://dx.doi.org/10.1002/syst.201900044

13.09.2019

C. Wanzke, A. Jussupow, F. Kohler, H. Dietz, V. R. I. Kaila and J. Boekhoven

ChemSystemsChem http://dx.doi.org/10.1002/syst.201900044

Abstract

Synthetic lipid membranes have served as important models for cellular membranes. However, these static membranes do not recapitulate the dynamic nature of the biological membranes which are frequently remodeled to support cellular function. An ideal membrane model would thus also display dynamic exchange of lipids. In this work, we achieve such a system by coupling the self-assembly of peptides into membranes with a chemical reaction cycle. The reaction cycle activates and deactivates the peptides for self-assembly at the expense of a chemical fuel. The resulting membranes are dynamically remodeled, and, over their 40-minute lifetime, they emerge, grow, and are torn apart before they eventually decay.


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